The aim of this study is to compare anti-gravity treadmill training with traditional treadmill training in patients with moderate to severe knee osteoarthritis.
Inclusion Criteria: * Female patients ≥ 50 and ≤ 75 years old * Patients with a diagnosis of knee OA in at least one knee according to the classification criteria of the American College of Rheumatology * Patients with Kellgren-Lawrence (K-L) knee OA staging III to IV * Patients reporting knee pain on most days of the past month * Patients with stable medical and psychological status * Patients willing to participate in the study Exclusion Criteria: Patients with serious cardiovascular, pulmonary, neurological disease or other musculoskeletal problems (inflammatory rheumatic disease, active synovitis, severe low back pain, hip/knee joint replacement or other hip/knee-related trauma, fracture, or surgery) that impair walking * Patients with a history of corticosteroid injection to the knee in the last 3 months * Patients who have received opioid analgesics or systemic corticosteroids in the last 3 months * Patients who have undergone any exercise program or physical therapy program for the lower extremities in the last 3 months * Patients with severe vision, hearing and language problems * Patients with a body mass index ≥35 kg /m²