This study is to characterize mitochondrial DNA (mtDNA) populations in adults with eye injuries and eye diseases. The eye exam is often hindered by the clouding of tissues involved in injury or disease. This protocol examines the use of mtDNA populations as indicators of developing inflammation and resolution of injury. This may be used to provide proactive treatment or define appropriate treatment needs beyond the indications of an ophthalmological exam.
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Inclusion Criteria: * a) Target group 1. Age ≥ 20 years old 2. Subjects must not be nursing, pregnant or planning to become pregnant. Subjects of child bearing potential must have a documented negative pregnancy test at the time of preoperative assessment or not be of child bearing potential. Identified eye disease including but not limited to age-related macular degeneration, glaucoma and/or diabetic retinopathy. 3. Scheduled ophthalmic surgery with expected vitreal humor discard. 4. Subject has provided written informed consent to participate in this protocol. b) Control group <!-- --> 1. Age ≥ 20 years old 2. Subjects must not be nursing, pregnant or planning to become pregnant. Subjects of child bearing potential must have a documented negative pregnancy test at the time of preoperative assessment or not be of child bearing potential. 3. Lack of identified eye disease. 4. Scheduled ophthalmic surgery with expected vitreal humor discard. 5. Subject has provided written informed consent to participate in this protocol. Exclusion Criteria: * a) Target group 1. Age \< 20 years old 2. Subject is nursing, pregnant, planning to become pregnant or of child bearing potential and does not agree to the use of reliable method of contraception during their participation in the study. A pregnancy test must be administered to women of childbearing potential at the time of preoperative assessment. 3. Identified eye disease including but not limited to age-related macular degeneration, glaucoma and/or diabetic retinopathy. 4. Subject has not completed informed consent to participate in this protocol. b) Scheduled ophthalmic surgery with expected vitreal humor discard Control group <!-- --> 1. Age \< 20 years old 2. Subject is nursing, pregnant, planning to become pregnant or of child bearing potential and does not agree to the use of reliable method of contraception during their participation in the study. A pregnancy test must be administered to women of childbearing potential at the time of preoperative assessment. 3. Lack of identified eye disease. 4. Subject has not completed informed consent to participate in this protocol. Scheduled ophthalmic surgery with expected vitreal humor discard.