The aim of the intervention is to gain insight into the long term effect of dietary fatty acid quality on insulin sensitivity and health parameters in healthy men. Whole body and peripheral insulin sensitivity were measured, together with analyses of plasma hormones and metabolites. The plasma proteome was also analyzed. Molecular adaptations in skeletal muscle and adipose tissue were subject for investigation. Furthermore, gut microbiota population number and diversity will be analyzed from faeces samples obtained before and after the intervention.
Inclusion Criteria: * healthy male subjects * 27-45 years * BMI 22-31 * maximal oxygen uptake \<48 ml/kg/min Exclusion Criteria: * smokers * use of medication * parents with type-2 diabetes